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Index > Protein center > Smad4(Gene name) > Mouse
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  • Smad4 (Gene name),
  • Mothers against decapentaplegic homolog 4 (Protein name ),  SMAD4_MOUSE from NCBI database.
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  • Gene name:
    Smad4(Dpc4;Madh4);
    Protein name:
    Mothers against decapentaplegic homolog 4(MAD homolog 4;Mothers against DPP homolog 4);
    Alternative:
    SMAD family member 4(SMAD 4;Smad4);Deletion target in pancreatic carcinoma 4 homolog;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer (By similarity). Heterotrimer; with a C-terminally phosphorylated R-SMAD molecule and to form the transcriptionally active SMAD2/3-SMAD4 complex (By similarity). Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with USP9X. Interacts with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Interacts with CITED1 and CITED2.
    Function:
    Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor.
    Subcellular Location:
    Cytoplasm Nucleus In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD.
    Protein Attributes:
    Sequence length:
    551
    Sequence:
    50:
    MDNMSITNTP | TSNDACLSIV | HSLMCHRQGG | ESETFAKRAI | ESLVKKLKEK | 
    100:
    KDELDSLITA | ITTNGAHPSK | CVTIQRTLDG | RLQVAGRKGF | PHVIYARLWR | 
    150:
    WPDLHKNELK | HVKYCQYAFD | LKCDSVCVNP | YHYERVVSPG | IDLSGLTLQS | 
    200:
    NAPSMLVKDE | YVHDFEGQPS | LPTEGHSIQT | IQHPPSNRAS | TETYSAPALL | 
    250:
    APAESNATST | TNFPNIPVAS | TSQPASILAG | SHSEGLLQIA | SGPQPGQQQN | 
    300:
    GFTAQPATYH | HNSTTTWTGS | RTAPYTPNLP | HHQNGHLQHH | PPMPPHPGHY | 
    350:
    WPVHNELAFQ | PPISNHPAPE | YWCSIAYFEM | DVQVGETFKV | PSSCPVVTVD | 
    400:
    GYVDPSGGDR | FCLGQLSNVH | RTEAIERARL | HIGKGVQLEC | KGEGDVWVRC | 
    450:
    LSDHAVFVQS | YYLDREAGRA | PGDAVHKIYP | SAYIKVFDLR | QCHRQMQQQA | 
    500:
    ATAQAAAAAQ | AAAVAGNIPG | PGSVGGIAPA | ISLSAAAGIG | VDDLRRLCIL | 
    550:
    RMSFVKGWGP | DYPRQSIKET | PCWIEIHLHR | ALQLLDEVLH | TMPIADPQPL | 
    551:
    D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MAD homolog 4
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    Cat.:
    U1925p
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    Packing:
    96T
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    MSDS:
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    Polyclonal Antibody for Mouse MAD homolog 4
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    P1925Rb-r
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    Packing:
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    Polyclonal Antibody for Mouse MAD homolog 4
    Cat.:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MAD homolog 4
    Polyclonal Antibody for Mouse MAD homolog 4
    Polyclonal Antibody for Mouse MAD homolog 4
    Cat.:
    P1925Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MAD homolog 4
    Monoclonal Antibody for Mouse MAD homolog 4
    Monoclonal Antibody for Mouse MAD homolog 4
    Monoclonal Antibody for Mouse MAD homolog 4
    Monoclonal Antibody for Mouse MAD homolog 4
    Protein for Mouse MAD homolog 4
    Protein for Mouse MAD homolog 4
    Protein for Mouse MAD homolog 4
    Protein for Mouse MAD homolog 4
    Protein for Mouse MAD homolog 4

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    References
    1. 1.
      "Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene."
      Anna C.H. , Devereux T.R.
      Mamm. Genome8:443-444(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: A/J.
      tissue: Lung.
    2. 2.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Olfactory epithelium.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-551
      strain: C57BL/6J.
      tissue: Lung.
    5. 5.
      "SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer."
      Lee K.H. , Evans S. , Ruan T.Y. , Lassar A.B.
      Development131:4709-4723(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;IDENTIFICATION IN A COMPLEX WITH SMAD1 AND YY1
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors."
      Baburajendran N. , Palasingam P. , Narasimhan K. , Sun W. , Prabhakar S. , Jauch R. , Kolatkar P.R.
      Nucleic Acids Res.38:3477-3488(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 9-140 IN COMPLEX WITH DNA;ZINC_BINDING SITES;SUBUNIT
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